Date d'affichage : 1/8/2017
Description du poste : Project: Physiology and pathology of development and function of basal ganglia – towards understanding and treatment of neurologic diseases
The project aims at characterizing basic mechanisms of neurogenesis in developing and adult striatum with particular focus on retinoid receptor signaling. Relevance of obtained data for understanding etiology and physiopathology of neurologic disorders including in particular restless legs syndrome (RLS; one of the most frequent neurodevelopmental disorders) will be investigated using new genetic mouse model of disease. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. It will benefit from such location and state-of-the-art infrastructure and expertise in developmental biology, animal behavior and pharmacology, genomics and bioinformatics. In addition, close collaboration with world leaders in clinical research in RLS and neurodegeneration will be mandatory to identify relevance of obtained data for the clinical condition and test new strategies of therapy.
Personne à contacter :
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
Formation requise : We are looking for highly motivated post-doctoral fellow with solid research experience in molecular and cell biology, and biochemistry (experience in developmental neurobiology, primary mammalian cell cultures or life imaging will be a great asset). Experience in work with rodent models is encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the 2 1/2 year challenging project and participate in animating team’s life.
Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists in one PDF file) by email.